Pathomorphological changes in the liver of rats after subchronic oral administration of gadolinium orthovanadate nanoparticles against the background of food stress

Abstract

The paper presents the results of preclinical studies of gadolinium orthovanadate nanoparticles, namely, pathomorphological studies of the liver of white rats. As an object of research, 140 sexually mature male white rats of the Wistar line were used, and the animals were divided into four groups of 35 rats each according to the principle of analogs. During the experiment, the control group received drinking water without additives, while the first experimental group was given a solution of gadolinium orthovanadate nanoparticles at 0.03 mg/kg body weight; rats of the second experimental group received 0.15 mg/kg body weight, and rats of the third experimental group received 0.3 mg/kg body weight. Watering was carried out for 56 days; then it was stopped, and the rats were observed for another 14 days. At 14, 28, 42, and 56 days after the start of the administration of nanoparticle solutions, and 14 days after its termination, seven rats from each group were euthanized and liver samples were taken for histomorphological studies. The results indicated that administering nanoparticles at doses of 0.03 and 0.15 mg/kg body weight to white rats via drinking water for 42 and 28 days, respectively, enhanced liver functional activity. However, increasing the dose of nanoparticles up to 0.3 mg/kg body weight under conditions of food stress leads to a decrease in the adaptive capacity of the liver, which results in the activation of destructive processes, vascular disorders, and inflammation.