Prolactin stimulates endocytosis of Staphylococcus aureus in bovine mammary ephithelial cells

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JOSÉ LUÍS ANAYA LÓPEZ
ANGELINA GUTIÉRREZ BARROSO
LETICIA LARA ZÁRATE
PEDRO DAMIÁN LOEZA LARA
JOEL EDMUNDO LÓPEZ MEZA
ALEJANDRA OCHOA ZARZOSA

Abstract

BOVINE MASTITIS PROVOKES INFL AMMATION OF THE MAMMARY GLAND AND IS MAINLY CAUSED BY STAPHYLOCOCCUS AUREUS. HIGHEST INCIDENTE OCCURS AT DRYING OFF PERIOD AND PARTURITION, WHERE PROLACTIN (PRL) HAS A RELEVANT FUNCTION, ALTHOUGH ITS ROLE IN THE INFECTION HAS NOT BEEN STUDIED. IN THIS WORK, IN VITRO EFFECT OF THE BOVINE PRL (1-50 NG/ML) ON ENDOCYTOSIS AND INTRACELLULAR PROLIFERATION OF S. AUREUS (ATCC 27543) IN BOVINE MAMMARY EPITHELIAL CELLS (BMEC) WAS EVALUATED. THE BMEC TREATED DURING 24 H WITH 5 NG/ML OF BPRL INCREASES ~3 FOLD THE ENDOCYTOSIS OF S. AUREUS, BESIDES INDUCING BACTERIAL PROLIFERATION. THIS EFFECT WAS SPECIFICALLY REVERTED BY TREATING THE BMEC WITH IGG ANTI-BPRL. S. AUREUS INCREASED (~3 FOLD) ITS ENDOCYTOSIS IN BMEC TREATED WITH BPRL (5 NG/ML), BUT THE NUMBER OF INFECTED CELLS WAS NOT MODIFIED. IN CONCLUSION, THE BPRL STIMULATES THE ENDOCYTOSIS AND THE PROLIFERATION OF S. AUREUS IN BMEC.
Keywords:
BOVINE MASTITIS PROLACTIN STAPHYLOCOCCUS AUREUS ENDOCYTOSIS

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