Detection of mammary adenocarcinoma metastases in a cat through 99mTc-thymine scintigraphy

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Paulo S. Castelo-Branco
Faculdade de Medicina. Departamento de Radiologia. Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
http://orcid.org/0000-0001-8188-1222
Gabriel Gutfilen-Schlesinger
Faculdade de Medicina. Departamento de Radiologia. Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
http://orcid.org/0000-0002-9577-4310
Priscila Sena
Sociedade União internacional protetora dos animais (SUIPA), Rio de Janeiro, Brazil
http://orcid.org/0000-0002-4502-8678
Guile Gutfilen-Schlesinger
Faculdade de Medicina. Departamento de Radiologia. Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
http://orcid.org/0000-0003-1760-2633
Sergio A.L. Souza
Faculdade de Medicina. Departamento de Radiologia. Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
http://orcid.org/0000-0002-7901-4805
Bianca Gutfilen
Faculdade de Medicina. Departamento de Radiologia. Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
http://orcid.org/0000-0001-8632-7474

Abstract

Mammary adenocarcinomas with metastases are more common in dogs than in cats. Their incidence is 1 in every 4,000 cats. In routine veterinary practice, laboratory exams for diagnosis of these neoplasms are nonspecific and scarcely used. Even though invasive procedure, biopsy, and histopathological findings are the gold standards that define the clinical approach, the clinical evaluation, and image assessment lead the way to the proper treatment, especially when surgical intervention is a possibility. This study describes the clinical signs, histopathological aspects, radiological and scintigraphic findings of a cat with mammary adenocarcinoma and metastases evaluated one hour after intravenous administration of 99mTc-thymine. Our focus was not to discuss the pathological aspects of the disease but the Nuclear Medicine role in metastases detection. Metastases, when lesser than 4mm, could go unnoticed by radiological exams, whereas scintigraphy may detect them. Using 99mTc-thymine scintigraphy, we successfully detected unsuspected metastases in the lungs, liver, and right kidney. Early diagnosis is the key to a better rate of survival due to the given treatment and prognostic. Hence, we strongly recommend the use of 99mTc-thymine scintigraphy as a complementary tool for breast cancer diagnosis in veterinary care.
Keywords:
oncology, scintigraphy, adenocarcinoma, diagnosis
DOI: https://doi.org/10.22201/fmvz.24486760e.2020.2.718

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