Generalities in canine papillomavirus: systematic review of case reports
Article Sidebar
Main Article Content
Abstract
Canine papillomavirus (CPV) is a common entity in dogs that can be transmitted by direct and indirect contact and cause lesions in various parts of the body. It is the main cause of benign tumors; however, if not detected in time, it is a risk factor for the development of squamous cell carcinoma, documented with high mortality. To clarify demographic generalities, location of lesions, and findings involved in CPV detection, a systematic review of case reports of CPV was performed. The PRISMA statement was followed. Literature was searched in PubMed, DOAJ, and CAB Abstracts from 2011 to date. The articles collected were tabulated in Excel with the variables of interest. A total of 54 articles were obtained from the search, and 11 were included in the review after the screening and selection process. The analysis of the information allowed us to identify that among the case reports there were 4 investigations with male dogs, 2 females and 5 unspecified. Age ranged from 2 to 12 years. The breed with more cases reported was the Labrador retriever and 6 reported cases with neutered patients. Regarding the location of the lesions, the most common was the oral cavity, and the main findings were the need to identify new subtypes of CPV, and the development of lesions at lower CD4 and CD8 lymphocyte counts. Further research, encouragement of veterinary medical personnel, and dissemination of CPVrelated literature are needed to make this pathology visible and initiate future public health actions.
Article Details
References
Zhou D, Luff J, Paul S, Alkhilaiwi F, Usuda Y, Wang N, Affolter V, Moore P, Schlegel R, Yuan H. Complete genome sequence of canine papillomavirus type 12. Genome Announcements. 2015;3(2):e00294-15. doi:10.1128/genomeA.00294-15.
Cavana P, Hubert B, Cordonnier N, Carlus M, Favrot C, Bensignor E. Generalized verrucosis associated with canine papillomavirus 9 infection in a dog. Veterinary Dermatology. 2015;26(3):209–210. doi: 10.1111/vde.12200.
Lange CE, Diallo A, Zewe C, Ferrer L. Novel canine papillomavirus type 18 found in pigmented plaques. Papillomavirus Research. 2016;2(1):159. doi:10.1016/j.pvr.2016.08.001.
Raj PAA, Pavulraj, S, Kumar MA, Sangeetha S, Shamugapriya R, Sabithabanu S. Therapeutic evaluation of homeopathic treatment for canine oral papillomatosis. Veterinary World. 2020;13(1):206–213. doi:10.14202/vetworld.2020.206-213.
Bhatta TR, Chamings A, Vibin J, Alexandersen S. Detection and characterisation of canine astrovirus, canine parvovirus and canine papillomavirus in puppies using next generation sequencing. Scientific Reports. 2019;9(1):4602. doi:10.1038/s41598-019-41045-z.
Munday JS, Lam ATH, Sakai M. Extensive progressive pigmented viral plaques in a Chihuahua dog. Veterinary Dermatology. 2022;33(3):252–254. doi:10.1111/vde.13056.
Anis EA, Frank LA, Francisco R, Kania SA. Identification of canine papillomavirus by PCR in Greyhound dogs. PeerJ. 2016;4:e2744. doi:10.7717/peerj.2744.
Cruz-Gregorio A, Aranda-Rivera AK, Pedraza-Chaverri J. Pathological similarities in the development of papillomavirus-associated cancer in humans, dogs, and cats. Animals. 2022;12(18):2390. doi:10.3390/ani12182390.
Wypij JM. A naturally occurring feline model of head and neck squamous cell carcinoma. Pathology Research International. 2013;2013:502197. doi:10.1155/2013/502197.
Rethlefsen ML, Kirtley S, Waffenschmidt S, Ayala AP, Moher D, Page MJ, Koffel JB. PRISMA-S: an extension to the PRISMA statement for reporting literature searches in systematic reviews. Systematic Reviews. 2021;10(1):39. doi:10.1186/s13643-020-01542-z.
Riley DS, Barber MS, Kienle GS, Aronson JK, von Schoen-Angerer T, Tugwell P, Kiene H, et al. CARE guidelines for case reports: explanation and elaboration document. Journal of Clinical Epidemiology. 2017;89(2):218–235. doi:10.1016/j.jclinepi.2017.04.026.
Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, Savović J, Schulz KF, Weeks L, Sterne JAC. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928. doi:10.1136/bmj.d5928.
Lange CE, Tobler K, Lehner A, Vetsch E, Favrot C. A case of a canine pigmented plaque associated with the presence of a Chi-papillomavirus. Veterinary Dermatology. 2012;23(1):76-e19. doi:10.1111/j.1365-3164.2011.01007.x.
Regalado Ibarra AM, Legendre L, Munday JS. Malignant transformation of a canine papillomavirus type 1-induced persistent oral papilloma in a 3-year-old dog. Journal of Veterinary Dentistry. 2018;35(2):79–95. doi:10.1177/0898756418774575.
Valle ACV. Homeopathic treatment of oral papillomatosis in dogs (Canis familiaris)-Case Report. International Journal of Science and Research. 2021;10(9), 487–491. doi:10.21275/SR21907103139.
Richman AW, Kirby AL, Rosenkrantz W, Muse R. Persistent papilloma treated with cryotherapy in three dogs. Veterinary Dermatology. 2017;28(6):625-e154. doi:10.1111/vde.12469.
Sumathi D, Ramesh P, Pazhanivel N, Bhavani MS, Singh KA, Jayathangaraj MG. Management of cutaneous papilloma in a Labrador dog-a case report. Indian Veterinary Journal. 2019;96(12):42–43.
Munday JS, Tucker RS, Kiupel M, Harvey CJ. Multiple oral carcinomas associated with a novel papillomavirus in a dog. Journal of Veterinary Diagnostic Investigation. 2015;27(2):221–225. doi:10.1177/1040638714567191.
Gang D-G, Sim C-H, Lee T-J, Kong J-Y, Hong I-H. Sebaceous cell differentiation in a canine oral papilloma. Journal of Veterinary Diagnostic Investigation. 2018;30(4):569–571. doi:10.1177/1040638718779102.
Orbell HL, Munday JS, Orbell GMB, Griffin CE. Development of multiple cutaneous and follicular neoplasms associated with canine papillomavirus type 3 in a dog. Veterinary Dermatology. 2020;31(5):401–403. doi: 10.1111/vde.12872.
Nwoha RI. A case report on natural regression of oral papillomatosis in a dog. International Journal of Microbiology Research and Reviews. 2015;4(1):127–129.
Yu M, Chambers JK, Tsuzuki M, Yamashita N, Ushigusa T, Haga T, Nakayama H, Uchida K. Pigmented viral plaque and basal cell tumor associated with canine papillomavirus infection in Pug dogs. Journal of Veterinary Medical Science. 2019;81(11):1643–1648. doi:10.1292/jvms.19-0384.
Munday JS, Dunowska M, Laurie RE, Hills S. Genomic characterisation of canine papillomavirus type 17, a possible rare cause of canine oral squamous cell carcinoma. Veterinary Microbiology. 2016;182(1):135–140. doi:10.1016/j.vetmic.2015.11.015.
Iyori K, Inai K, Shimakura H, Haga T, Shimoura H, Imanishi I, Imai A, Iwasaki T. Spontaneous regression of canine papillomavirus type 2-related papillomatosis on footpads in a dog. Journal of Veterinary Medical Science. 2019;81(6):933–936. doi:10.1292/jvms.19-0136.
Chang C-Y, Chen W-T, Haga T, Yamashita N, Lee C-F, Tsuzuki M, Chang H-W. The detection and association of canine papillomavirus with benign and malignant skin lesions in dogs. Viruses. 2020;12(2):170. doi:10.3390/v12020170.
Sharma S, Boston SE, Skinner OT, Perry JA, Verstraete FJ, Lee DB, et al. Survival time of juvenile dogs with oral squamous cell carcinoma treated with surgery alone: a Veterinary Society of Surgical Oncology retrospective study. Veterinary Surgery. 2021;50(4):740–747. doi:10.1111/vsu.13625.
Putnová B, Burová J, Georgiou M, Fichtel T, Stehlík L, Frgelecová L, Škorič M. Occurrence site of canine oral lesions: a retrospective study of 659 cases. Acta Veterinaria Brno. 2020;89(2):179–187. doi:10.2754/avb202089020179.
Bradley CW, Luff JA, Mauldin EA. Clinicopathological findings of canine seborrhoeic keratosis with comparison to pigmented viral plaques. Veterinary Dermatology. 2013;24(4):432-e95. doi:10.1111/vde.12039.
Thaiwong T, Sledge DG, Wise AG, Olstad K, Maes RK, Kiupel M. Malignant transformation of canine oral papillomavirus (CPV1)-associated papillomas in dogs: An emerging concern? Papillomavirus Research. 2018;6:83–89. doi:10.1016/j.pvr.2018.10.007.
Malsawmsangi L, Dawngliana MS. Pathomorphological study on canine papilloma: a case report. Pharma Innovation. 2019;8(7):726–727.
Luff J, Rowland P, Mader M, Orr C, Yuan H. Two canine papillomaviruses associated with metastatic squamous cell carcinoma in two related Basenji dogs. Veterinary Pathology. 2016;53(6):1160–1163. doi:10.1177/0300985816630795.
Hansen N, Nicholas N, Pack G, Mackie JT, Shipstone M, Munday JS, Reddell P, Orbell G, Malik R. Progressive cutaneous viral pigmented plaques in three Hungarian Vizslas and the response of lesions to topical tigilanol tiglate gel. Veterinary Medicine and Science. 2017;4(1):53–62. doi:10.1002/vms3.85.
Goldschmidt MH, Kennedy JS, Kennedy DR, Yuan H, Holt DE, Casal ML, Traas AM, Mauldin EA, Moore PF, Henthorn PS, Hartnett BJ, Weinberg KI, Schlegel R, Felsburg PJ. Severe papillomavirus infection progressing to metastatic squamous cell carcinoma in bone marrow-transplanted X-linked SCID dogs. Journal of Virology. 2006;80(13):6621–6628. doi:10.1128/JVI.02571-05.
Yağci BB, Ural K, Öcal N, Haydardedeoğlu AE. Azithromycin therapy of papillomatosis in dogs: a prospective, randomized, double-blinded, placebo-controlled clinical trial. Veterinary Dermatology. 2008;19(4):194–198.
doi:10.1111/j.1365-3164.2008.00674.x.
Williams A, Scally G, Langland J. A topical botanical therapy for the treatment of canine papilloma virus associated oral warts: A case series. Advances in Integrative Medicine. 2021;8(2):151–154. doi:10.1016/j.aimed.2020.12.003.
Fantini O, Vidémont E, Pin D. Successful treatment of florid papillomatosis in a dog using subcutaneous feline recombinant interferon-ω. Revue de Médecine Vétérinaire. 2015;166(1-2):25–29.
Nicholls PK, Stanley MA. Canine papillomavirus—A centenary review. Journal of Comparative Pathology. 1999;120(3):219–233. doi:10.1053/jcpa.1998.0278.
Gould AP, Coyner KS, Trimmer AM, Tater K, Rishniw M. Canine pedal papilloma identification and management: a retrospective series of 44 cases. Veterinary Dermatology. 2021;32(5):509-e141. doi:10.1111/vde.12999.
Zhou D, Wang A, Maxwell S, Schlegel R, Yuan H. Long-term culture of canine ocular cells that maintain canine papillomaviruses. Viruses. 2022;14(12):2675. doi:10.3390/v14122675.
Tisza MJ, Yuan H, Schlegel R, Buck CB. Genomic sequence of canine papillomavirus 19. Genome Announc. 2016;4(6):e01380-16. doi:10.1128/genomeA.01380-16.
Oğuzoğlu TÇ, Timurkan MÖ, Koç BT, Alkan F. Comparison of genetic characteristics of canine papillomaviruses in Turkey. Infection, Genetics and Evolution. 2017;55:372–376. doi:10.1016/j.meegid.2017.10.010.
License
Veterinaria México OA by Facultad de Medicina Veterinaria y Zootecnia - Universidad Nacional Autónoma de México is licensed under a Creative Commons Attribution 4.0 International Licence.
Based on a work at http://www.revistas.unam.mx
- All articles in Veterinaria México OA re published under the Creative Commons Attribution 4.0 Unported (CC-BY 4.0). With this license, authors retain copyright but allow any user to share, copy, distribute, transmit, adapt and make commercial use of the work, without needing to provide additional permission as long as appropriate attribution is made to the original author or source.
- By using this license, all Veterinaria México OAarticles meet or exceed all funder and institutional requirements for being considered Open Access.
- Authors cannot use copyrighted material within their article unless that material has also been made available under a similarly liberal license.