Eprinomectin and levamisole action on gastrointestinal nematodes in a Mexican dairy goat production system
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Abstract
The effectiveness of eprinomectin and levamisole was evaluated in a dairy goat herd in El Bajío with a history of multi-resistance to fenbendazole (0 %) and ivermectin (70 %) using the Fecal Egg Count Reduction Test. Larval cultures were used to assess the epidemiology of the disease. Thirty goats with ≥ 150 eggs per gram (EPG) and no anthelmintic treatment for ≥ 60 days were selected. The modified McMaster technique (sensitivity: 50 EPG) was used to quantify the parasite burden. Three groups (n = 10) were weighed and treated: eprinomectin (0.5 mg/kg, topical), levamisole (12 mg/kg, subcutaneous), and an untreated control. The effectiveness of eprinomectin was 65 %, while that of levamisole was 100 %. Trichostrongylus spp. (90–100 %) and Oesophagostomum sp. (10 %) were identified. The reduced effectiveness of eprinomectin may be linked to ivermectin resistance. Multidrug resistance in small ruminants highlights the urgent need for targeted selective treatments and integrated parasite management to preserve effective anthelmintics.
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