Comparación de las constantes fisiológicas sanguíneas de los ratones cd1, heterocigotico et/+ y desnudo et/et

Abstract

IS PAPER THE NORMAL BLOOD VALUES OF A NEW NAKED MICE MUTANT KNOWN AS ET/ET WERE COMPARED VS CD 1 AND HETEROCIGOTIC ET/. LEUKOCYTE AND DIFFERENTIAL COUNTS SHOWED THAT TOTAL LEUKOCYTES, LYMPHOCYTES, MONOCYTES AND EOSINOPHILS WERE SIGNIFICANTLY HIGHER (P < 0.05) IN THE ET/ET MICE THAN IN THE CD 1, AND THAT THERE WAS NO DIFFERENCE WITH THE ET/ ONES. IN 89% OF THE NAKED MICE, NEUTROPHIL HYPERSEGMENTATION WAS OBSERVED, WHILE ONLY A 10% OF THE HETEROCYGOTES PRESENTED IT, AND IT WAS NOT OBSERVED IN CD 1 MICE. TOTAL LYMPHOCYTES CD3 AND CD8 POPULATIONS, WAS HIGHER IN ET/ET (P<0.05) THAN IN CD 1 MICE, AND WITHOUT DIFFERENCE IN ET/ MICE. HEMATOCRITE VALUES WERE HIGHER (P<0.05) IN THE ET/ET MICE THAN IN CD 1 ONES. IN THE PLASMA PROTEIN COUNT, THE ET/ET MICE HAD LESS DENSITY AS COMPARED TO THE CD 1 ONES. THE ET/ET MALES PRESENTED A SIGNIFICANTLY HIGHER (P<0.05) CONCENTRATION IN THE ALPHAGLOBULIN FRACTION THAN IN THE ET/ET FEMALES (8.94% ± 1.81 VS 3.49% ± 0.69). THERE WERE SIGNIFICANT DIFFERENCES IN THE SPLEEN LYMPHOID CELL COUNT BETWEEN THE ET/ET MICE WHICH HAD 43 CELLS /50ML COMPARED TO 97.5 IN THE CD 1 MICE. MEANWHILE ET/ MICE HAD AN INTERMEDIATE VALUE THAT LACKED STATISTICAL SIGNIFICANCE. WITH THE RESULTS IN THE ANALYSES IT IS CONCLUDED THAT: THE ET/ET MICE HAVE WITHIN THEIR GENETIC CHARACTERISTICS A LEUKOCYTOSIS WITH LYMPHOCYTOSIS MONOCYTOSIS AND CIRCULATING EOSINOPHILIA, AND LYMPHOPENIA IN THE SPLEEN, AS WELL AS A NEUTROPHIL HYPERSEGMENTATION. THIS FINDING IS CONSIDERED AS AN ASSOCIATED POSSIBILITY TO ADRENAL HYPERTROPHY REPORTED BY OTHERS AUTHORS.