Evaluación de dos modelos quimioterapéuticos para el control de fasciolasis bovina en clima cálido húmedo en México

Abstract

IN ORDER TO EVALUATE 2 MODELS OF CHEMOTHERAPY AGAINST FASCIOLA HEPATICA IN NATURALLY INFECTED CATTLE LOCATED IN A FARM IN THE MUNICIPALITY OF NAUTLA IN THE STATE OF VERACRUZ IN MEXICO, TRICLABENDAZOLE (TBZ) WAS ADMINISTERED ONCE OR TWICE IN DIFFERENT MONTHS TO REDUCE FAECAL EGG OUTPUT IN A SIGNIFICANT WAY. FURTHERMORE, ANTI- F. HEPATICA ANTIBODY VALUES, AS WELL AS SERIC LEVELS OF GAMMA-GLUTAMYL TRANSPEPTIDASE (GGT) AND ASPARTATE AMINO TRANSFERASE (AST), WERE ALSO DETERMINED. TWO GROUPS (G) OF 23 ANIMALS EACH RECEIVED 12 MG/K OF TBZ. G-1, THE CONTROL GROUP, WAS TREATED IN JANUARY, WHEREAS G-2 IN JANUARY AND MAY. STOOL SAMPLES WERE COLLECTED FROM ALL ANIMALS EVERY 45 DAYS DURING 10 TIMES IN ORDER TO PERFORM FAECAL EGG COUNT PER 5 G (EPG). AT THE SAME TIME, BLOOD SAMPLES WERE COLLECTED FROM 15 COWS OF EACH GROUP TO DETECT ANTI- F. HEPATICA ANTIBODIES BY THE ELISA TEST, AND TO DETERMINE GGT- AND AST ENZYMES BY SPECTROPHOTOMETRY. IMPROVEMENT PERCENTAGE FOR EPG WAS 27.6% HIGHER IN G-2 THAN IN G-1; THIS EPG AGREES WITH THE LOWER VALUES OF GGT DETECTED IN G-2, AND AST ACTIVITY DID NOT EXCEED THE NORMAL LIMIT. ANTIBODY LEVELS WERE POSITIVE, AND WERE NOT AFFECTED BY THE TREATMENT IN ANY OF THE GROUPS.