Seroprevalence of Encephalitozoon cuniculi in companion rabbits in Mexico City
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Abstract
Encephalitozoon cuniculi is an obligate intracellular microorganism primarily found in rabbits, although it has also been reported in various species such as horses, rodents, dogs, monkeys, foxes, cats, goats, and pigs. Immunodeficient humans are also vulnerable to this infection. This study aimed to determine the seroprevalence of E. cuniculi in 89 companion rabbits in Mexico City using an enzyme-linked immunosorbent assay (ELISA). The results indicated a seroprevalence of 70 %. Clinically healthy rabbits constituted 92 % of the sample, of which 68 % were positive for antibodies against E. cuniculi. The findings align with global reports of high seroprevalence. Despite most infections being subclinical, a substantial portion of asymptomatic rabbits were seropositive, highlighting the need for early disease recognition to prevent its spread. This study is the first to describe the seroprevalence of E. cuniculi in Mexico and the common associated signs.
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References
Doboşi AA, Bel LV, Paştiu AI, Pusta DL. A review of Encephalitozoon cuniculi in domestic rabbits (Oryctolagus cuniculus): Biology, clinical signs, diagnostic techniques, treatment, and prevention. Pathogens. 2022;11(12):1486. doi: 10.3390/pathogens11121486. DOI: https://doi.org/10.3390/pathogens11121486
Malčeková B, Halánová M, Sulínová Z, Molnár L, Ravaszová P, Adam J, et al. Seroprevalence of antibodies to Encephalitozoon cuniculi and Encephalitozoon intestinalis in humans and animals. Research in Veterinary Science. 2010;89(3):358−361. doi: 10.1016/j.rvsc.2010.03.020. DOI: https://doi.org/10.1016/j.rvsc.2010.03.020
Latney L, Bradley C, Wyre N. Encephalitozoon cuniculi in pet rabbits: diagnosis and optimal management. Veterinary Medicine: Research and Reports. 2014;5:169−180. doi: 10.2147/VMRR.S49842. DOI: https://doi.org/10.2147/VMRR.S49842
Van Gool T, Biderre C, Delbac F, Wentink-Bonnema E, Peek R, Vivares CP. Serodiagnostic studies in an immunocompetent individual infected with Encephalitozoon cuniculi. The Journal of Infectious Diseases. 2004;189(12):2243−2249. doi: 10.1086/421117. DOI: https://doi.org/10.1086/421117
Weber R, Deplazes P, Flepp M, Mathis A, Baumann R, Sauer B, et al. Cerebral microsporidiosis due to Encephalitozoon cuniculi in a patient with human immunodeficiency virus infection. The New England Journal of Medicine. 1997;336(7):474−478. doi: 10.1056/NEJM199702133360704 DOI: https://doi.org/10.1056/NEJM199702133360704
Enriquez FJ, Taren D, Cruz-López A, Muramoto M, Palting JD, Cruz P. Prevalence of intestinal encephalitozoonosis in Mexico. Clinical Infectious Diseases, 1998;26(5):1227−1229. doi: 10.1086/520278. DOI: https://doi.org/10.1086/520278
Chilón VJ. Seroprevalencia de Encephalitozoon cuniculi en conejos destinados como mascotas en la provincia de Lima. [Thesis dissertation]. Lima, Perú: Universidad Nacional Mayor de San Marcos; 2014.
Maestrini G, Ricci E, Cantile E, Mannella R, Mancianti F, Paci G, et al. Encephalitozoon cuniculi in rabbits: Serological screening and histopathological findings. Comparative Immunology, Microbiology and Infectious Diseases. 2017;50:54−57. doi: 10.1016/j.cimid.2016.11.012 DOI: https://doi.org/10.1016/j.cimid.2016.11.012
Shin JC, Kim DG, Kim SH, Kim S, Song KH. Seroprevalence of Encephalitozoon cuniculi in pet rabbits in Korea. The Korean Journal of Parasitology. 2014;52(3):321−323. doi: 10.3347/kjp.2014.52.3.321. DOI: https://doi.org/10.3347/kjp.2014.52.3.321
Keeble EJ, Shaw DJ. Seroprevalence of antibodies to Encephalitozoon cuniculi in domestic rabbits in the United Kingdom. Veterinary Record. 2006;158(16):539−544. doi: 10.1136/vr.158.16.539. DOI: https://doi.org/10.1136/vr.158.16.539
García MC, Maldonado R. Prevalencia y hallazgos radiográficos en conejos, cuyos y chinchillas diagnosticados con maloclusión en el Hospital Veterinario de Especialidades en Fauna Silvestre y Etología Clínica de la UNAM, México. Revista de la Facultad de Medicina Veterinaria y Zootecnia. 2020;67(1):17−32. doi: 10.15446/rfmvz.v67n1.87676. DOI: https://doi.org/10.15446/rfmvz.v67n1.87676
United Kingdom Pet Food. Rabbit Size-O-Meter. 2024. https://www.ukpetfood.org/resource/rabbit-size-o-meter.html
Vargas R. Estadística II. Programa Administración Pública Territorial.1ª ed. Bogotá, Colombia: Escuela Superior de Administración Pública; 2008. p.43−46.
Hein J, Flock U, Sauter-Louis C, Hartmann K. Encephalitozoon cuniculi in rabbits in Germany: prevalence and sensitivity of antibody testing. Veterinary Record. 2014;174(14):350. doi: 10.1136/vr.102126. DOI: https://doi.org/10.1136/vr.102126
Berger S, Cray C, Turner A, Reifur L, Montiani-Ferreira F. Seroprevalence of Encephalitozoon cuniculi infection in pet rabbits in Brazil. Journal of Exotic Pet Medicine. 2015;24(4):435−440. doi: 10.1053/j.jepm.2015.08.010. DOI: https://doi.org/10.1053/j.jepm.2015.08.010
Dipineto L, Rinaldi L, Santaniello A, Sensale M, Cuomo A, Calabria M, et al. Serological survey for antibodies to Encephalitozoon cuniculi in pet rabbits in Italy. Zoonoses and Public Health. 2008;55(3):173−175. doi: 10.1111/j.1863-2378.2007.01097.x. DOI: https://doi.org/10.1111/j.1863-2378.2007.01097.x
Giordano C, Weigt A, Vercelli A, Rondena M, Grilli G, Giudice C. Immunohistochemical identification of Encephalitozoon cuniculi in phacoclastic uveitis in four rabbits. Veterinary Ophtalmology. 2005;8(4):271−275. doi: 10.1111/j.1463-5224.2005.00394.x. DOI: https://doi.org/10.1111/j.1463-5224.2005.00394.x
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