Anti-ro/ssa, anti-la/ssb autoantibodies and antiphospholipid antibodies in serum of et/et mutant mice that show exocrinopathy

Abstract

IN THIS PAPER, THE ANTI-RO/SSA, ANTI-LA/SSB AND ANTI-PHOSPHOLIPID ANTIBODIES' TITERS IN SERUM OF NUDE MUTANT MICE OF ET/ET, ET/ (HETEROZYGOUS) AND STRAINS, WERE COMPARATIVELY STUDIED, AND ANTIBODIES"" TITERS WERE CORRELATED WITH THE SEVERITY OF MAXILLARY AND LACRIMAL GLANDS' LESIONS. RESULTS SHOWED THAT GROSS OCULAR LESIONS WERE ASSOCIATED TO THE MUTANT STRAIN ET/ET. IN THIS STRAIN THE GLANDULAR WEIGHT HAD A NEGATIVE CORRELATION WITH THE AGE (R = -0.370, P = 0.011), THE PRESENCE OF ANTI-RO/SSA AND ANTI-LA/SSB AUTOANTIBODIES SHOWED 13.5% AND 10.5% OF POSITIVITY, RESPECTIVELY, AND BOTH ANTIBODIES WERE ASSOCIATED TO THE ET/ET STRAIN, ONLY 1/5 OF THE SERA GAVE POSITIVE TO BOTH AUTOANTIBODIES. THE ANOVA TEST OF ANTIPHOSPHOLIPID ANTIBODY'S TITERS BETWEEN THE STRAINS SHOWED INCREASED TITERS OF IGM AND IGG ANTIBODIES IN THE ET/ET STRAIN, COMPARED TO THE AND ET/ STRAINS (P = 0.00 AND P = 0.004, RESPECTIVELY). THE WEIGHT OF THE LACRIMAL GLANDS SHOWED A NEGATIVE CORRELATION WITH THE PRESENCE OF ANTI RO/SSA ANTIBODIES (R = ""0.381, P = 0.009). WHEN THE CORRELATION WAS BETWEEN THESE AUTOANTIBODY TITERS AND THE AGE, THE RESULT WAS POSITIVE (R = 0.403, P = 0.006). THE RESULTS OF THIS RESEARCH SHOW THAT THE MUTANT STRAIN ET/ET PRESENTS SIGNS THAT RESEMBLE THE SJÖGREN SYNDROME.