Inducción experimental de anestesia general en potros con la administración intravenosa de isoflurano

Abstract

A STUDY DIVIDED IN TWO PHASES WAS PERFORMED IN ORDER TO EVALUATE THE INDUCTION OF GENERAL ANESTHESIA IN FOALS WITH AN INTRAVENOUS ADMINISTRATION OF ISOFLURANE. HEPARINIZED EQUINE BLOOD WAS USED FOR PHASE I ( IN VITRO) AND 5 FOALS WERE USED FOR PHASE II ( IN VIVO). RESULTS FOR THE IN VITRO PHASE SHOWED CHANGES IN VALUES OF HCT, GR, HB AND CHCM. HOWEVER, THERE WAS NO DAMAGE TO THE CELLS"" INTEGRITY, WHICH PROVIDED CONFIDENCE TO CONTINUE WITH THE IN VIVO PHASE. RESULTS OF THE HEMATOLOGY BEFORE- AND AFTER THE ADMINISTRATION OF ISOFLURANE WERE ONLY SIGNIFICANTLY DIFFERENT FOR THE DOSE OF 0.01 ML ISOFLURANE/KG BODY WEIGHT. PHYSIOLOGIC VARIABLES WERE NOT AFFECTED BY ANY DOSE. CLINICAL VARIABLES (TIME BEFORE THE FOAL STOOD AND TOTAL TIME LYING DOWN) SHOWED SIGNIFICANT DIFFERENCES FOR 0.04 OR 0.06 ML OF ISOFLURANE/KG BODY WEIGHT, IN CONTRAST TO THOSE VALUES FOR THE LOWER DOSES. THE 0.04- OR 0.06-ML DOSE OF ISOFLURANE WAS THE DOSE THAT PRODUCED INDUCTION OF ANESTHESIA. BASED ON THE RESULTS OF THIS STUDY, IT IS SUGGESTED THAT THE INTRAVENOUS ROUTE OF ADMINISTRATION OF ISOFLURANE MAY BE A NEW POSSIBILITY, BUT IT IS INDISPENSABLE TO COMPLETE MORE STUDIES TO DETERMINE CLINICAL RECOMMENDATIONS FOR ITS FURTHER USE.