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Although various methods have been used in the treatment of bovine cutaneous papillomatosis (BCP), no definite treatment has yet been established. There are no studies regarding the efficacy of azithromycin (AZ) and of any combination of trypsin, chymotrypsin, and papain proteolytic enzymes (PEC) in the treatment of BCP. The objective of this study was to investigate the efficacy of AZ and PEC in the treatment of BCP. A total of 24 female Holstein cattle of 6-17 months of age with spontaneous BCP were used for this study. In addition to the clinical findings, the diagnosis was confirmed with histopathological examinations. The animals were divided at random into three groups (n = 8). The AZ group received 10 mg/kg/day PO for 10 days. In the PEC group, an injectable suspension of proteolytic enzymes was applied IM at 0.4 mL/10 kg dose, 3 times with 8-10 days interval and the spray was used topically once a day for 10 days. The control group (CO) was not treated. The mean in papilloma warts decreased 92.4 % in the AZ group, 83.38 % in the PEC group, and 59.48 % in the CO. There were statistically significant differences in warts presence decreases between the three groups (P < 0.05). Both AZ and PEC were considered successful for the BCP treatment. However, AZ was found more effective than PEC.
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